Progesterone regulates catechol-O-methyl transferase gene expression in breast cancer cells: Distinct effect of progesterone receptor isoforms
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چکیده
منابع مشابه
Progesterone negatively regulates BCRP in progesterone receptor-positive human breast cancer cells.
BACKGROUND/AIMS Breast cancer resistance protein (BCRP) plays a crucial role in multidrug resistance (MDR). Previous studies have shown that steroid hormones, like progesterone (PROG), regulate BCRP expression. The presence of a progesterone response element (PRE) in the BCRP promoter, suggests that PROG may regulate transcription of BCRP. METHODS To investigate the role of PROG in the regula...
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Catechol-O-methyl transferase (COMT) plays a key role in the degradation of brain dopamine (DA). Specifically, low COMT activity results in higher DA levels in the prefrontal cortex (PFC), thereby reducing the vulnerability for attentional and cognitive deficits in both psychotic and healthy individuals. COMT activity is markedly reduced by a non-synonymous single-nucleotide polymorphism (SNP) ...
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Breast cancer is the most common malignant tumor among women. It accounts for 22% of all female cancers; more than twice the prevalence of cancer in women at any other site. Immunohistochemistry (IHC) is now the globally accepted methodology for detection of estrogen (ER) and progesterone (PR) receptors in breast carcinomas. The present study is designed for further insight into age and biology...
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ژورنال
عنوان ژورنال: The Journal of Steroid Biochemistry and Molecular Biology
سال: 2007
ISSN: 0960-0760
DOI: 10.1016/j.jsbmb.2007.03.049